Find an Invisalign® doctor near you today. Meynardi F, Pasqualini ME, Rossi F, et al. Correlation between dysfunctional occlusion and periodontal bacterial profile. J Biol Regul Homeost Agents. 2016;30(2 Suppl 1):115-121. *Implantology and Maxillofacial Surgery, Malocclusion: Causes, Symptoms, Treatments and Consequences. Maxillo-Faciale Clinique MFML. Published April 6, 2021. Accessed August 30, 2023. **Based on lower Plaque Index (PI), Probing Depth (PD), and Bleeding on Probing (BOP) of the upper right first molar and upper left central incisors at initial, 1 month and 3 months on 77 patients (age 16-30, 32 Invisalign treatment, 35 fixed appliances, 10 control) in Class I mild crowding cases. ***20M is the number of patients treated by the Invisalign system. Data on file at Align Technology, as of March 31, 2025.